Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome
Comprehensive molecular‐level models of human metabolism have been generated on a
cellular level. However, models of whole‐body metabolism have not been established as …
cellular level. However, models of whole‐body metabolism have not been established as …
Harmonizing semantic annotations for computational models in biology
Life science researchers use computational models to articulate and test hypotheses about
the behavior of biological systems. Semantic annotation is a critical component for …
the behavior of biological systems. Semantic annotation is a critical component for …
Plants in silico: why, why now and what?—an integrative platform for plant systems biology research
A paradigm shift is needed and timely in moving plant modelling from largely isolated efforts
to a connected community endeavour that can take full advantage of advances in computer …
to a connected community endeavour that can take full advantage of advances in computer …
Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform
Multi-scale models can facilitate whole plant simulations by linking gene networks, protein
synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further …
synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further …
[HTML][HTML] The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach
Aging is a biological process characterized by the progressive functional decline of many
interrelated physiological systems. In particular, aging is associated with the development of …
interrelated physiological systems. In particular, aging is associated with the development of …
Bridging the genotype–phenotype gap: what does it take?
The genotype–phenotype map (GP map) concept applies to any time point in the ontogeny
of a living system. It is the outcome of very complex dynamics that include environmental …
of a living system. It is the outcome of very complex dynamics that include environmental …
[HTML][HTML] Multiscale modeling in disease
ANF Versypt - Current opinion in systems biology, 2021 - Elsevier
Multiscale computational modeling aims to connect the complex networks of effects at
different length and/or time scales. For example, these networks often include intracellular …
different length and/or time scales. For example, these networks often include intracellular …
Challenges and opportunities in cardiovascular health informatics
Cardiovascular health informatics is a rapidly evolving interdisciplinary field concerning the
processing, integration/interpretation, storage, transmission, acquisition, and retrieval of …
processing, integration/interpretation, storage, transmission, acquisition, and retrieval of …
[HTML][HTML] JSim, an open-source modeling system for data analysis
E Butterworth, BE Jardine, GM Raymond, ML Neal… - …, 2013 - ncbi.nlm.nih.gov
JSim is a simulation system for develo** models, designing experiments, and evaluating
hypotheses on physiological and pharmacological systems through the testing of model …
hypotheses on physiological and pharmacological systems through the testing of model …
Tuneable resolution as a systems biology approach for multi‐scale, multi‐compartment computational models
The use of multi‐scale mathematical and computational models to study complex biological
processes is becoming increasingly productive. Multi‐scale models span a range of spatial …
processes is becoming increasingly productive. Multi‐scale models span a range of spatial …