Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

The endocannabinoids are a family of lipid messengers that engage the cell surface
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Cannabinoid receptors are molecular targets for marijuana and hashish, the widespread
drugs of abuse. These receptors are expressed in areas of the central nervous system that …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons
from the consequences of abnormal discharge activity have been postulated. We generated …

Epidemiological studies have documented a reduced prevalence of Alzheimer's disease
among users of nonsteroidal anti-inflammatory drugs (NSAIDs),,,,. It has been proposed that …

Abstract Changes in synaptic efficacy are thought to be crucial to experience-dependent
modifications of neural function. The diversity of mechanisms underlying these changes is …

The existence of an endogenous cannabinoid system was demonstrated conclusively with
the discovery of endogenous brain constituents capable of activating the cannabinoid …