Abstract miRNA are short non-coding RNA responsible for the knockdown of proteins
through their targeting and silencing of complimentary mRNA sequences. The miRNA …

Abstract Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP) are retinal
degenerative disorders that dramatically damage the retina. As there is no therapeutic …

Loss of function (LoF) of TAR-DNA binding protein 43 (TDP-43) and mis-localization,
together with TDP-43-positive and hyperphosphorylated inclusions, are found in post …

Pathogenic mutations of transactivation response element DNA-binding protein 43 (TDP-43)
are closely linked with amyotrophic lateral sclerosis (ALS). It was recently reported that two …

Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease mostly resulting
from a complex interplay between genetic, environmental and lifestyle factors. Common …

Background Diabetic retinopathy (DR) is the microvascular ocular complication of diabetes
mellitus (DM), which can lead to irreversible blindness and visual impairment if not properly …

Misfolding of superoxide dismutase-1 (SOD1) has been correlated with many
neurodegenerative diseases, such as Amyotrophic lateral sclerosis's and Alzheimer's …

Aggregation of TAR DNA-binding protein 43 kDa (TDP-43) is thought to drive the
pathophysiology of amyotrophic lateral sclerosis and some frontotemporal dementias. TDP …

MicroRNA-124a (miR-124a) is one of the most abundantly expressed microRNAs in the
central nervous system and is encoded in mammals by the three genomic loci miR-124a …

Retinal degeneration is an increasing global burden without cure for the majority of patients.
Once retinal cells have degenerated, vision is permanently lost. Different strategies have …