The diverse microbial community that inhabits the human gut has an extensive metabolic
repertoire that is distinct from, but complements the activity of mammalian enzymes in the …

Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous
progress in the understanding of cellular mechanisms, disease progression, and the …

The human microbiome influences the efficacy and safety of a wide variety of commonly
prescribed drugs. Designing precision medicine approaches that incorporate microbial …

A multitude of factors contribute to complex diseases and can be measured with 'omics'
methods. Databases facilitate data interpretation for underlying mechanisms. Here, we …

A reflection of our ultimate understanding of a complex system is our ability to control its
behavior. Typically, control has multiple prerequisites: it requires an accurate map of the …

Background The human gut microbiome performs important functions in human health and
disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of …

Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

A great variety of systems in nature, society and technology–from the web of sexual contacts
to the Internet, from the nervous system to power grids–can be modeled as graphs of …

Multiple models of human metabolism have been reconstructed, but each represents only a
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus' …

Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …