From organ-on-a-chip to human-on-a-chip: A review of research progress and latest applications

Y Huang, T Liu, Q Huang, Y Wang - ACS sensors, 2024 - ACS Publications
Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and
functionality of human organs on a microfluidic chip, is undergoing significant technological …

The evolution of microfluidic‐based drug‐loading techniques for cells and their derivatives

S Tong, J Niu, Z Wang, Y Jiao, Y Fu, D Li, X Pan… - Small, 2024 - Wiley Online Library
Conventional drug delivery techniques face challenges related to targeting and adverse
reactions. Recent years have witnessed significant advancements in nanoparticle‐based …

Hydrogel Strain Sensors for Integrating Into Dynamic Organ‐on‐a‐Chip

W She, C Shen, Z Xue, B Zhang, G Zhang, Q Meng - Small, 2025 - Wiley Online Library
Current hydrogel strain sensors have never been integrated into dynamic organ‐on‐a‐chip
(OOC) due to the lack of sensitivity in aqueous cell culture systems. To enhance sensing …

[HTML][HTML] Human organoids-on-chips for biomedical research and applications

H Wang, X Ning, F Zhao, H Zhao, D Li - Theranostics, 2024 - ncbi.nlm.nih.gov
Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …

Multifunctional MXene-Based Platforms for Soft and Bone Tissue Regeneration and Engineering

S Iravani, E Nazarzadeh Zare… - … Biomaterials Science & …, 2024 - ACS Publications
MXenes and their composites hold great promise in the field of soft and bone tissue
regeneration and engineering (TRE). However, there are challenges that need to be …

[HTML][HTML] Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology

S Yuan, H Yuan, DC Hay, H Hu, C Wang - Biosensors, 2024 - mdpi.com
Traditional drug development is a long and expensive process with high rates of failure. This
has prompted the pharmaceutical industry to seek more efficient drug development …

[HTML][HTML] Emerging microfluidics for the modeling and treatment of arthritis

N Yang, C Sun, C Dong, Y Huang, Y Zhu, Z Gu - Engineered Regeneration, 2024 - Elsevier
Microfluidic is a technology that allows the precise control of fluid in a micro-channel. With its
advantages of high throughput and low cost, microfluidic technology has achieved good …

Nanomedicine for cancer patient‐centered care

C Sorrentino, SL Ciummo, C Fieni, E Di Carlo - MedComm, 2024 - Wiley Online Library
Cancer is a leading cause of morbidity and mortality worldwide, and an increase in
incidence is estimated in the next future, due to population aging, which requires the …

Structural color heart-on-a-chip for evaluating the myocardial protection effects of traditional Chinese medicine

X Guo, L Sun, D Xu, Y Zhao - Chemical Engineering Journal, 2025 - Elsevier
Many Chinese medicines have shown protective effects on the heart, while their specific
effects and modes of action are still lacking of intuitive studies. In this paper, we propose a …

Recent advances in Organ-on-a-Chip models: How precision engineering integrates cutting edge technologies in fabrication and characterization

S Sadeghzade, MH Hooshiar, H Akbari… - Applied Materials …, 2024 - Elsevier
There is an increasing need for better preclinical therapeutic development models suitable
for the human body. As a result, there has been a shift from traditional animal models to …