AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Alzheimer's disease (AD) remains one of the most formidable neurological disorders,
affecting millions globally. This review provides a holistic overview of the therapeutic …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …

AD is a chronic neurodegenerative disease. Many different signaling pathways, such as
Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer's disease …

Antibiotic resistance is one of the main public health concerns of this century. This resistance
is also associated with oxidative stress, which could contribute to the selection of resistant …

Our present work demonstrates the molecular hybridization-assisted design, synthesis, and
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …

Acetylcholinesterase (AChE) catalyzes the conversion of Aβ peptide to its aggregated form
and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also …

Background Recent reports have highlighted the significance of plant bioactive components
in drug development targeting neurodegenerative disorders such as Alzheimer's disease …

Despite the vital activity of many compounds, they lack that effectiveness due to their low
solubility in water. Unfortunately, for this reason, rutin often leads to low tissue permeability …

Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …