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Peptides as pharmacological carriers to the brain: promises, shortcomings and challenges
S Parrasia, I Szabò, M Zoratti… - molecular …, 2022 - ACS Publications
Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …
ABC transporters at the blood–brain interfaces, their study models, and drug delivery implications in gliomas
D Gomez-Zepeda, M Taghi, JM Scherrmann… - Pharmaceutics, 2019 - mdpi.com
Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …
Age-related functional and expressional changes in efflux pathways at the blood-brain barrier
F Erdő, P Krajcsi - Frontiers in Aging Neuroscience, 2019 - frontiersin.org
During the last decade, several articles have reported a relationship between advanced age
and changes in the integrity of the blood-brain barrier (BBB). These changes were …
and changes in the integrity of the blood-brain barrier (BBB). These changes were …
Sexual differences in mitochondrial and related proteins in rat cerebral microvessels: a proteomic approach
S Cikic, PK Chandra, JC Harman… - Journal of Cerebral …, 2021 - journals.sagepub.com
Sex differences in mitochondrial numbers and function are present in large cerebral arteries,
but it is unclear whether these differences extend to the microcirculation. We performed an …
but it is unclear whether these differences extend to the microcirculation. We performed an …
Cannabidiol increases proliferation, migration, tubulogenesis, and integrity of human brain endothelial cells through TRPV2 activation
H Luo, E Rossi, B Saubamea… - Molecular …, 2019 - ACS Publications
The effect of cannabidiol (CBD), a high-affinity agonist of the transient receptor potential
vanilloid-2 (TRPV2) channel, has been poorly investigated in human brain microvessel …
vanilloid-2 (TRPV2) channel, has been poorly investigated in human brain microvessel …
Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses
N Choublier, M Taghi, MC Menet, M Le Gall… - Fluids and Barriers of …, 2022 - Springer
Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived
from the blood circulation, including shear stress (SS). ECs are able to detect SS and …
from the blood circulation, including shear stress (SS). ECs are able to detect SS and …
[PDF][PDF] Pharmacokinetics and toxicokinetics roles of membrane transporters at kidney level
J Veiga-Matos, F Remião… - Journal of Pharmacy & …, 2020 - frontierspartnerships.org
Transporters are large membrane proteins, which control the passage of various
compounds through biological membranes. These proteins are divided into uptake and …
compounds through biological membranes. These proteins are divided into uptake and …
In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition
Y Murata, S Neuhoff, A Rostami-Hodjegan, H Takita… - The AAPS journal, 2022 - Springer
Drug development for the central nervous system (CNS) is a complex endeavour with low
success rates, as the structural complexity of the brain and specifically the blood-brain …
success rates, as the structural complexity of the brain and specifically the blood-brain …
Development of an antibody-free ID-LC MS method for the quantification of procalcitonin in human serum at sub-microgram per liter level using a peptide-based …
HH Huynh, A Bœuf, M Derbez-Morin, AM Dupuy… - Analytical and …, 2021 - Springer
The quantification of low abundant proteins in complex matrices by liquid chromatography
coupled to tandem mass spectrometry (LC-MS/MS) remains challenging. A measurement …
coupled to tandem mass spectrometry (LC-MS/MS) remains challenging. A measurement …
Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis
Isolated brain capillaries are essential for analyzing the changes of protein expressions at
the blood–brain barrier (BBB) under pathological conditions. The standard brain capillary …
the blood–brain barrier (BBB) under pathological conditions. The standard brain capillary …