The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis
by activating the unfolded protein response (UPR). However, UPR can trigger cell death …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

The endoplasmic reticulum (ER) is a critical organelle, storing the majority of calcium and
governing protein translation. Thus, it is crucial to keep the homeostasis in all ER …

Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid
hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an …

Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …

Most of the secreted and plasma membrane proteins are synthesized on membrane-bound
ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident …