The last few years have witnessed an unprecedented increase in the number of novel
bacterial species that hold potential to be used for metabolic engineering. Historically …

Bacteria often encounter temperature fluctuations in their natural habitats and must adapt to
survive. The molecular response of bacteria to sudden temperature upshift or downshift is …

Antibacterial agents target the products of essential genes but rarely achieve complete
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …

Bacillus subtilis is a Gram-positive model bacterium with extensive documented annotation.
However, with the rise of high-throughput techniques, the amount of complex data being …

Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel
mechanisms of action that are capable of treating drug-resistant infections. Many antibiotics …

Gene essentiality is a founding concept of genetics with important implications in both
fundamental and applied research. Multiple screens have been performed over the years in …

Bacillus subtilis is the best studied model organism of the Gram-positive lineage. It is
naturally transformable and has an extremely powerful genetic toolbox. It is fast growing and …

Recent discoveries have implicated the gut microbiome in the progression and severity of
Parkinson's disease; however, how gut bacteria affect such neurodegenerative disorders …

The vast majority of bacteria, including human pathogens and microbiome species, lack
genetic tools needed to systematically associate genes with phenotypes. This is the major …

Bacillus subtilis is the most characterized gram-positive bacterium that has significant
attributes, such as growing well on cheap carbon sources, possessing clear inherited …