Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges

H Geerts, J Wikswo, PH van der Graaf… - CPT …, 2020 - Wiley Online Library
The substantial progress made in the basic sciences of the brain has yet to be adequately
translated to successful clinical therapeutics to treat central nervous system (CNS) diseases …

Importancia de la farmacometría en el desarrollo de productos biológicos

KB Saborío, RM Avilés, VP Salazar… - Revista Médica de la …, 2023 - revistas.ucr.ac.cr
La farmacometría es una ciencia interdisciplinaria que utiliza herramientas matemáticas y
estadísticas para el modelado de datos, con el fin de apoyar el proceso de desarrollo de …

Approaches towards prediction of CNS PK and PD

ECM Lange, HY Chang, D Shah - Drug Delivery to the Brain: Physiological …, 2022 - Springer
It has to be realized that a drug's pharmacokinetics and pharmacodynamics results from the
combination of drug properties and biological system characteristics. This chapter will …