Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

The multicellular organization of diverse systems, including embryos, intestines, and tumors
relies on coordinated cell migration in curved environments. In these settings, cells establish …

Collective cell migrations drive morphogenesis, wound healing, and cancer dissemination.
Cells located at the front are considered leaders while those behind them are defined …

Cells often migrate on curved surfaces inside the body, such as curved tissues, blood
vessels, or highly curved protrusions of other cells. Recent in vitro experiments provide clear …

Coordinated cellular movements are key processes in tissue morphogenesis. Using a cell-
based modeling approach we study the dynamics of epithelial layers lining surfaces with …

Migrating cell collectives navigate complex tissue environments both during normal
development and in pathological contexts such as tumor invasion and metastasis. To do …

Among the physicochemical cues in the cellular microenvironment that orchestrate cell
processes, the different levels of curvature in the extracellular matrix and intrinsic to the …

The importance of physical forces in the morphogenesis, homeostatic function, and
pathological dysfunction of multicellular tissues is being increasingly characterized, both …

The coordinated movement of cell collectives is essential for normal epithelial tissue
development, maintenance, and cancer progression. Here, we report on a minimal 3D …