Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy
The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …
in both breast cancer (BC) development and progression. The treatment of choice in women …
[HTML][HTML] Urine as a source of liquid biopsy for cancer
Simple Summary Tissue biopsy is essential for diagnosis and characterization of a tumor.
Recently circulating tumor cells and other tumor-derived nucleic acid can be detected from …
Recently circulating tumor cells and other tumor-derived nucleic acid can be detected from …
Current and emerging applications of droplet digital PCR in oncology
The clinical management of cancer has evolved in recent years towards more personalized
strategies that require a comprehensive knowledge of the complex molecular features …
strategies that require a comprehensive knowledge of the complex molecular features …
Concordance of genomic alterations by next-generation sequencing in tumor tissue versus circulating tumor DNA in breast cancer
YK Chae, AA Davis, S Jain, C Santa-Maria… - Molecular cancer …, 2017 - aacrjournals.org
While identifying genomic alterations in tumor tissue is the current gold-standard technique
for molecular profiling, circulating tumor DNA (ctDNA) represents a noninvasive method of …
for molecular profiling, circulating tumor DNA (ctDNA) represents a noninvasive method of …
[HTML][HTML] Clinical utility of liquid biopsy-based actionable mutations detected via ddPCR
Cancer is one of the leading causes of death worldwide and remains a major public health
challenge. The introduction of more sensitive and powerful technologies has permitted the …
challenge. The introduction of more sensitive and powerful technologies has permitted the …
Personalized medicine in breast cancer: pharmacogenomics approaches
Breast cancer is the fifth cause of cancer death among women worldwide and represents a
global health concern due to the lack of effective therapeutic regimens that could be applied …
global health concern due to the lack of effective therapeutic regimens that could be applied …
Principles of digital PCR and its applications in current obstetrical and gynecological diseases
X Mao, C Liu, H Tong, Y Chen… - American journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Digital PCR (dPCR) is a revolutionary technique to precisely quantify nucleic acids. For its
high sensitivity and specificity, this technique has been widely replicated worldwide. To …
high sensitivity and specificity, this technique has been widely replicated worldwide. To …
[HTML][HTML] ESR1 mutations: Moving towards guiding treatment decision-making in metastatic breast cancer patients
Mutations in the gene coding for the estrogen receptor (ER), ESR1, have been associated
with acquired endocrine resistance in patients with ER-positive metastatic breast cancer …
with acquired endocrine resistance in patients with ER-positive metastatic breast cancer …
ESR1 mutations: a new biomarker in breast cancer
Introduction: In hormone receptor-positive breast cancer, ESR1 mutations have emerged as
a key mechanism of resistance to endocrine therapy. Areas covered: Here, we review …
a key mechanism of resistance to endocrine therapy. Areas covered: Here, we review …
Kinetics, prognostic and predictive values of ESR1 circulating mutations in metastatic breast cancer patients progressing on aromatase inhibitor
F Clatot, A Perdrix, L Augusto, L Beaussire… - …, 2016 - pmc.ncbi.nlm.nih.gov
Purpose To assess the prognostic and predictive value of circulating ESR1 mutation and its
kinetics before and after progression on aromatase inhibitor (AI) treatment. Patients and …
kinetics before and after progression on aromatase inhibitor (AI) treatment. Patients and …