Cytokines that control the immune response were shown to have efficacy in preclinical
murine cancer models. Interferon (IFN)-α is approved for treatment of hairy cell leukemia …

Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is
essential for the development, proliferation, and activation of immune cells, including natural …

Abstract Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death
of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in …

Communication of molecular species through dynamic association and/or dissociation at
various cellular sites governs biological functions. Understanding these physiological …

IL2 and IL15, members of the 4α-helix bundle family of cytokines, play pivotal roles in the
control of the life and death of lymphocytes. Although their heterotrimeric receptors have two …

▪ Abstract Interleukin-15 (IL-15) is a 14-to 15-kDa member of the 4 α-helix bundle family of
cytokines. IL-15 expression is controlled at the levels of transcription, translation, and …

The fluid mosaic membrane model proved to be a very useful hypothesis in explaining
many, but certainly not all, phenomena taking place in biological membranes. New …

Background Interleukin-2 (IL-2) plays a pivotal role in immune homeostasis due to its ability
to stimulate numerous lymphocyte subsets including natural killer (NK) cells, effector CD4+ …

Erythropoietin and other cytokine receptors are thought to be activated through hormone-
induced dimerization and autophosphorylation of JAK kinases associated with the receptor …

The activation of Stat5 proteins (Stat5a and Stat5b) is one of the earliest signaling events
mediated by IL-2 family cytokines, allowing the rapid delivery of signals from the membrane …