Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Recent progress in phospholipase A2 research: from cells to animals to humans
M Murakami, Y Taketomi, Y Miki, H Sato… - Progress in lipid …, 2011 - Elsevier
Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …
related enzymes, which are subdivided into several classes including low-molecular-weight …
SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes
BACKGROUND SARS-CoV-2 plasma viremia has been associated with severe disease and
death in COVID-19 in small-scale cohort studies. The mechanisms behind this association …
death in COVID-19 in small-scale cohort studies. The mechanisms behind this association …
The phospholipase A2 superfamily and its group numbering system
RH Schaloske, EA Dennis - … et Biophysica Acta (BBA)-Molecular and Cell …, 2006 - Elsevier
The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …
Phospholipase A2 enzymes
I Kudo, M Murakami - Prostaglandins & other lipid mediators, 2002 - Elsevier
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …
Biochemistry and Physiology of Mammalian Secreted Phospholipases A2
Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …
A new era of secreted phospholipase A2
M Murakami, H Sato, Y Miki, K Yamamoto… - Journal of lipid …, 2015 - ASBMB
Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences
Peptidoglycan recognition proteins (PGRPs) are innate immunity molecules that are present
in most invertebrate and vertebrate animals. All PGRPs function in antimicrobial defence …
in most invertebrate and vertebrate animals. All PGRPs function in antimicrobial defence …
[LIBRO][B] Handbook of venoms and toxins of reptiles
SP Mackessy - 2016 - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shop**" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …
Properties of the Group IV phospholipase A2 family
M Ghosh, DE Tucker, SA Burchett, CC Leslie - Progress in lipid research, 2006 - Elsevier
The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly
called cytosolic phospholipase A2 (cPLA2) α, cPLA2β, cPLA2γ, cPLA2δ, cPLA2ε and …
called cytosolic phospholipase A2 (cPLA2) α, cPLA2β, cPLA2γ, cPLA2δ, cPLA2ε and …