Advancing the use of genome-wide association studies for drug repurposing

WR Reay, MJ Cairns - Nature Reviews Genetics, 2021 - nature.com
Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …

The role of vitamin D in health and disease: A narrative review on the mechanisms linking vitamin D with disease and the effects of supplementation

E Rebelos, N Tentolouris, E Jude - Drugs, 2023 - Springer
Vitamin D insufficiency or deficiency (VDD) is a very prevalent condition in the general
population. Vitamin D is necessary for optimal bone mineralization, but apart from the bone …

Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults: the DO-HEALTH …

HA Bischoff-Ferrari, B Vellas, R Rizzoli, RW Kressig… - Jama, 2020 - jamanetwork.com
Importance The benefits of vitamin D, omega-3 fatty acids, and exercise in disease
prevention remain unclear. Objective To test whether vitamin D, omega-3s, and a strength …

Vitamin D deficiency: consequence or cause of obesity?

L Vranić, I Mikolašević, S Milić - Medicina, 2019 - mdpi.com
Obesity is defined as an excess amount of body fat and represents a significant health
problem worldwide. High prevalence of vitamin D (VD) deficiency in obese subjects is a well …

7ª Diretriz brasileira de hipertensão arterial: apresentação

MVB Malachias - Arquivos brasileiros de cardiologia, 2016 - SciELO Brasil
A avaliação inicial de um paciente com hipertensão arterial sistêmica (HAS) inclui a
confirmação do diagnóstico, a suspeição e a identificação de causa secundária, além da …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

[HTML][HTML] Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis

N Liu, J Sun, X Wang, T Zhang, M Zhao, H Li - International Journal of …, 2021 - Elsevier
Background Observational studies suggest that the risk and clinical prognosis of coronavirus
disease 2019 (COVID-19) are related to low vitamin D status; however, the data are …

Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial

R Scragg, AW Stewart, D Waayer, CMM Lawes… - JAMA …, 2017 - jamanetwork.com
Importance Cohort studies have reported increased incidence of cardiovascular disease
(CVD) among individuals with low vitamin D status. To date, randomized clinical trials of …

Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials

P Autier, P Mullie, A Macacu, M Dragomir… - The lancet Diabetes & …, 2017 - thelancet.com
Randomised trials reported up to Dec 31, 2012, did not confirm that vitamin D
supplementation could protect from non-skeletal health conditions affecting adults, as was …