Status and prospects of genome‐wide association studies in plants

L Tibbs Cortes, Z Zhang, J Yu - The plant genome, 2021 - Wiley Online Library
Genome‐wide association studies (GWAS) have developed into a powerful and ubiquitous
tool for the investigation of complex traits. In large part, this was fueled by advances in …

Finding the genomic basis of local adaptation: pitfalls, practical solutions, and future directions

S Hoban, JL Kelley, KE Lotterhos… - The American …, 2016 - journals.uchicago.edu
Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

N Li, Q He, J Wang, B Wang, J Zhao, S Huang… - Nature Genetics, 2023 - nature.com
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …

A generalized linear mixed model association tool for biobank-scale data

L Jiang, Z Zheng, H Fang, J Yang - Nature genetics, 2021 - nature.com
Compared with linear mixed model-based genome-wide association (GWA) methods,
generalized linear mixed model (GLMM)-based methods have better statistical properties …

GAPIT version 3: boosting power and accuracy for genomic association and prediction

J Wang, Z Zhang - Genomics, Proteomics and Bioinformatics, 2021 - academic.oup.com
Genome-wide association study (GWAS) and genomic prediction/selection (GP/GS) are the
two essential enterprises in genomic research. Due to the great magnitude and complexity …

Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations

P Qin, H Lu, H Du, H Wang, W Chen, Z Chen, Q He… - Cell, 2021 - cell.com
Structural variations (SVs) and gene copy number variations (gCNVs) have contributed to
crop evolution, domestication, and improvement. Here, we assembled 31 high-quality …

rMVP: a memory-efficient, visualization-enhanced, and parallel-accelerated tool for genome-wide association study

L Yin, H Zhang, Z Tang, J Xu, D Yin… - Genomics …, 2021 - academic.oup.com
Along with the development of high-throughput sequencing technologies, both sample size
and SNP number are increasing rapidly in genome-wide association studies (GWAS), and …

Computationally efficient whole-genome regression for quantitative and binary traits

J Mbatchou, L Barnard, J Backman, A Marcketta… - Nature …, 2021 - nature.com
Genome-wide association analysis of cohorts with thousands of phenotypes is
computationally expensive, particularly when accounting for sample relatedness or …

[HTML][HTML] Pan-genome of wild and cultivated soybeans

Y Liu, H Du, P Li, Y Shen, H Peng, S Liu, GA Zhou… - Cell, 2020 - cell.com
Soybean is one of the most important vegetable oil and protein feed crops. To capture the
entire genomic diversity, it is needed to construct a complete high-quality pan-genome from …

Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet

J Chen, Y Liu, M Liu, W Guo, Y Wang, Q He, W Chen… - Nature Genetics, 2023 - nature.com
Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve
cereal production and quality, and ensure food security. Here we present the genetic …