Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding

M Barroso, MG Monaghan, R Niesner… - Advanced Drug Delivery …, 2023 - Elsevier
Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation

GCL Wong, JD Antani, PP Lele, J Chen, B Nan… - Physical …, 2021 - iopscience.iop.org
Bacterial biofilms are communities of bacteria that exist as aggregates that can adhere to
surfaces or be free-standing. This complex, social mode of cellular organization is …

Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

G Kim, D Ahn, M Kang, J Park, DH Ryu, YJ Jo… - Light: Science & …, 2022 - nature.com
The healthcare industry is in dire need of rapid microbial identification techniques for
treating microbial infections. Microbial infections are a major healthcare issue worldwide, as …

Chemical composition, antibacterial activity and study of the interaction mechanisms of the main compounds present in the Alpinia galanga rhizomes essential oil

C Zhou, C Li, S Siva, H Cui, L Lin - Industrial Crops and Products, 2021 - Elsevier
In this research, the antibacterial activity and the interaction mechanisms of the major
chemical constituent present in the Alpinia galanga rhizomes essential oil (AGREO) were …

Understanding Real-Time Fluorescence Signals from Bacteria and Wound Tissues Observed with the MolecuLight i:XTM

MY Rennie, D Dunham, L Lindvere-Teene, R Raizman… - Diagnostics, 2019 - mdpi.com
The persistent presence of pathogenic bacteria is one of the main obstacles to wound
healing. Detection of wound bacteria relies on sampling methods, which delay confirmation …

[HTML][HTML] Metabolic heterogeneity in clonal microbial populations

V Takhaveev, M Heinemann - Current opinion in microbiology, 2018 - Elsevier
Highlights•Cells of clonal microbial populations can vary in metabolite levels and metabolic
fluxes.•Ecological factors, inherent dynamics and molecular noise cause metabolic …

Environmental drivers of metabolic heterogeneity in clonal microbial populations

F Schreiber, M Ackermann - Current opinion in biotechnology, 2020 - Elsevier
Highlights•Phenotypic heterogeneity in metabolism is driven by nutrient limitation.•Nutrient
limitation underpins metabolic heterogeneity caused by temporal fluctuations in substrate …

Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis

A Dow, P Sule, TJ O'Donnell, A Burger… - PLoS …, 2021 - journals.plos.org
Mycobacterium tuberculosis (Mtb) has complex and dynamic interactions with the human
host, and subpopulations of Mtb that emerge during infection can influence disease …

[HTML][HTML] Optical methods for bacterial detection and characterization

C McGoverin, C Steed, A Esan, J Robertson, S Swift… - APL Photonics, 2021 - pubs.aip.org
Rapid identification and enumeration of bacteria are critical, given the surge of antibiotic-
resistance, global exchange of food products, and the use of bacteria for bioremediation …

[HTML][HTML] Itaconic acid and dimethyl itaconate exert antibacterial activity in carbon-enriched environments through the TCA cycle

LY **e, YB Xu, XQ Ding, S Liang, DL Li, AK Fu… - Biomedicine & …, 2023 - Elsevier
Itaconic acid (IA), a metabolite generated by the tricarboxylic acid (TCA) cycle in eukaryotic
immune cells, and its derivative dimethyl itaconate (DI) exert antibacterial functions in …