Bacteria secrete small molecules known as siderophores to acquire iron from their
surroundings. For over 60 years, investigations into the bioinorganic chemistry of these …

Antimicrobial resistance (AMR) is a global threat to society due to the increasing emergence
of multi-drug resistant bacteria that are not susceptible to our last line of defence antibiotics …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen responsible for
nosocomial infections. The prevalence of antibiotic-resistant P. aeruginosa strains is …

Background Fibroblast activation protein (FAP) is a proline selective serine protease that is
overexpressed in tumor stroma and in lesions of many other diseases that are characterized …

The design, synthesis, and characterization of enterobactin–antibiotic conjugates, hereafter
Ent-Amp/Amx, where the β-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are …

Siderophores are chelators synthesized by bacteria and fungi to sequester iron, which is
essential for virulence and pathogenicity. Since the process involves active transport, which …

A squaramide ester derivative of desferrioxamine B (H3DFO) that is compatible with
aqueous solvents and does not induce antibody aggregation is used to attach the …

Desferrioxamine B (DFOB) was discovered in the late 1950s as a hydroxamic acid
metabolite of the soil bacterium Streptomyces pilosus. The exquisite affinity of DFOB for Fe …

One of the factors necessary for the survivability and growth of microorganisms are iron ions.
For the uptake of this vital metal ion from the surrounding environment, microorganisms …