Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …

A central prediction of evolutionary theory is that energy invested into reproduction comes at
the expense of somatic maintenance and repair, accelerating biological aging. Supporting …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

DNA methylation clocks can accurately estimate chronological age and, to some extent, also
biological age, yet the process by which age-associated DNA methylation (DNAm) changes …

Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …