Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …
B cells in central nervous system disease: diversity, locations and pathophysiology
B cells represent a relatively minor cell population within both the healthy and diseased
central nervous system (CNS), yet they can have profound effects. This is emphasized in …
central nervous system (CNS), yet they can have profound effects. This is emphasized in …
[HTML][HTML] Beyond activation: characterizing microglial functional phenotypes
J Lier, WJ Streit, I Bechmann - Cells, 2021 - mdpi.com
Classically, the following three morphological states of microglia have been defined:
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …
The role of glial cells in multiple sclerosis disease progression
Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …
sclerosis (MS), limited progress has been made in addressing primary progressive or …
Ageing and multiple sclerosis
The factor that is most relevant and strongly associated with the clinical course of multiple
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …
Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics
E Kamma, W Lasisi, C Libner, HS Ng… - Journal of …, 2022 - Springer
There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
Meningeal inflammation as a driver of cortical grey matter pathology and clinical progression in multiple sclerosis
Growing evidence from cerebrospinal fluid samples and post-mortem brain tissue from
individuals with multiple sclerosis (MS) and rodent models indicates that the meninges have …
individuals with multiple sclerosis (MS) and rodent models indicates that the meninges have …
Neurovascular coupling in development and disease: focus on astrocytes
TL Stackhouse, A Mishra - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …
BTK inhibition limits B-cell–T-cell interaction through modulation of B-cell metabolism: implications for multiple sclerosis therapy
Abstract Inhibition of Bruton's Tyrosine Kinase (BTKi) is now viewed as a promising next-
generation B-cell-targeting therapy for autoimmune diseases including multiple sclerosis …
generation B-cell-targeting therapy for autoimmune diseases including multiple sclerosis …
Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner
General anesthesia leads to a loss of consciousness and an unrousable state in patients.
Although general anesthetics are widely used in clinical practice, their underlying …
Although general anesthetics are widely used in clinical practice, their underlying …