Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation
Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …
relatively recently has its wide-spread role in enzyme regulation and biology come to be …
The cytoophidium and its kind: filamentation and compartmentation of metabolic enzymes
JL Liu - Annual review of cell and developmental biology, 2016 - annualreviews.org
Compartmentation is essential for the localization of biological processes within a cell. In
2010, three groups independently reported that cytidine triphosphate synthase (CTPS), a …
2010, three groups independently reported that cytidine triphosphate synthase (CTPS), a …
Human CTP synthase filament structure reveals the active enzyme conformation
The universally conserved enzyme CTP synthase (CTPS) forms filaments in bacteria and
eukaryotes. In bacteria, polymerization inhibits CTPS activity and is required for nucleotide …
eukaryotes. In bacteria, polymerization inhibits CTPS activity and is required for nucleotide …
[HTML][HTML] Filamentation of metabolic enzymes in Saccharomyces cerevisiae
Compartmentation via filamentation has recently emerged as a novel mechanism for
metabolic regulation. In order to identify filament-forming metabolic enzymes systematically …
metabolic regulation. In order to identify filament-forming metabolic enzymes systematically …
Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments
EM Lynch, JM Kollman - Nature structural & molecular biology, 2020 - nature.com
Many enzymes assemble into defined oligomers, providing a mechanism for cooperatively
regulating activity. Recent studies have described a mode of regulation in which enzyme …
regulating activity. Recent studies have described a mode of regulation in which enzyme …
Cytoophidium assembly reflects upregulation of IMPDH activity
Cytidine triphosphate synthase (CTPS) and inosine monophosphate dehydrogenase
(IMPDH)(both of which have two isoforms) can form fiber-like subcellular structures termed …
(IMPDH)(both of which have two isoforms) can form fiber-like subcellular structures termed …
Filamentation modulates allosteric regulation of PRPS
HH Hu, GM Lu, CC Chang, Y Li, J Zhong, CJ Guo… - Elife, 2022 - elifesciences.org
Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine
and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal …
and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal …
Drosophila CTP synthase can form distinct substrate-and product-bound filaments
X Zhou, CJ Guo, HH Hu, J Zhong, Q Sun, D Liu… - Journal of Genetics and …, 2019 - Elsevier
Intracellular compartmentation is a key strategy for the functioning of a cell. In 2010, several
studies revealed that the metabolic enzyme CTP synthase (CTPS) can form filamentous …
studies revealed that the metabolic enzyme CTP synthase (CTPS) can form filamentous …
Metabolic regulation via enzyme filamentation
GN Aughey, JL Liu - Critical reviews in biochemistry and molecular …, 2016 - Taylor & Francis
Determining the mechanisms of enzymatic regulation is central to the study of cellular
metabolism. Regulation of enzyme activity via polymerization-mediated strategies has been …
metabolism. Regulation of enzyme activity via polymerization-mediated strategies has been …
CTP synthase forms the cytoophidium in human hepatocellular carcinoma
CTP synthase (CTPS) can aggregate into an intracellular macrostructure, the cytoophidium,
in various organisms including human cells. Previous studies have shown that assembly of …
in various organisms including human cells. Previous studies have shown that assembly of …