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Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus
SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2024 - Springer
The principles of cerebrospinal fluid (CSF) production, circulation and outflow and regulation
of fluid volumes and pressures in the normal brain are summarised. Abnormalities in these …
of fluid volumes and pressures in the normal brain are summarised. Abnormalities in these …
The need for mathematical modelling of spatial drug distribution within the brain
E Vendel, V Rottschäfer, ECM de Lange - Fluids and Barriers of the CNS, 2019 - Springer
The blood brain barrier (BBB) is the main barrier that separates the blood from the brain.
Because of the BBB, the drug concentration-time profile in the brain may be substantially …
Because of the BBB, the drug concentration-time profile in the brain may be substantially …
Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways
The kinetics of amyloid beta turnover within human brain is still poorly understood. We
previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not …
previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not …
Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system
Background As an alternative to advection, solute transport by shear-augmented dispersion
within oscillatory cerebrospinal fluid flow was investigated in small channels representing …
within oscillatory cerebrospinal fluid flow was investigated in small channels representing …
Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain
Cerebrospinal fluid (CSF) is essential for the development and function of the central
nervous system (CNS). However, the brain and its interstitium have largely been thought of …
nervous system (CNS). However, the brain and its interstitium have largely been thought of …
Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and …
Background Intrathecal drug delivery has a significant role in pain management and central
nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians in …
nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians in …
Translational approaches for brain delivery of biologics via cerebrospinal fluid
Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the
tissues of the central nervous system (CNS) by circumventing the blood‐brain barrier and …
tissues of the central nervous system (CNS) by circumventing the blood‐brain barrier and …
Preferential activation of proprioceptive and cutaneous sensory fibers compared to motor fibers during cervical transcutaneous spinal cord stimulation: a …
Objective. Cervical transcutaneous spinal cord stimulation (tSCS) is a promising technology
that can support motor function recovery of upper-limbs after spinal cord injury. Its efficacy …
that can support motor function recovery of upper-limbs after spinal cord injury. Its efficacy …
Anthropomorphic model of intrathecal cerebrospinal fluid dynamics within the spinal subarachnoid space: spinal cord nerve roots increase steady-streaming
Cerebrospinal fluid (CSF) dynamics are thought to play a vital role in central nervous system
(CNS) physiology. The objective of this study was to investigate the impact of spinal cord …
(CNS) physiology. The objective of this study was to investigate the impact of spinal cord …
Effect of normal breathing on the movement of CSF in the spinal subarachnoid space
BACKGROUND AND PURPOSE: Forced respirations reportedly have an effect on CSF
movement in the spinal canal. We studied respiratory-related CSF motion during normal …
movement in the spinal canal. We studied respiratory-related CSF motion during normal …