Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

JJ Urquijo-Ponce, C Alventosa-Mateu… - World Journal of …, 2024‏ - pmc.ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a high mortality neoplasm which usually appears on a
cirrhotic liver. The therapeutic arsenal and subsequent prognostic outlook are intrinsically …

[HTML][HTML] The omics technologies and liquid biopsies: Advantages, limitations, applications

D Magro, M Venezia, CR Balistreri - Medicine in Omics, 2024‏ - Elsevier
Over the last few years, the development of so-called omics technologies has greatly
contributed to the discovery of new biomarkers and targets, embracing various fields from …

Microfluidic biosensors for biomarker detection in body fluids: a key approach for early cancer diagnosis

Z Liu, Y Zhou, J Lu, T Gong, E Ibáñez, A Cifuentes… - Biomarker …, 2024‏ - Springer
Early detection of cancer significantly improves patient outcomes, with biomarkers offering a
promising avenue for earlier and more precise diagnoses. Microfluidic biosensors have …

Deep learning-based multimodal spatial transcriptomics analysis for cancer

P Rajdeo, B Aronow… - Advances in cancer …, 2024‏ - pmc.ncbi.nlm.nih.gov
The advent of deep learning (DL) and multimodal spatial transcriptomics (ST) has
revolutionized cancer research, offering unprecedented insights into tumor biology. This …

Treatment options for advanced hepatocellular carcinoma: the potential of biologics

F Rossari, S Foti, S Camera, M Persano… - Expert Opinion on …, 2024‏ - Taylor & Francis
Introduction Advanced hepatocellular carcinoma (HCC) represents a significant global
health burden, whose treatment has been recently revolutionized by the advent of biologic …

[PDF][PDF] Transcriptomic signature in advanced hepatocellular carcinoma tissue to predict combination immunotherapy response

H Kanzaki, Y Hoshida - Clinical and Molecular Hepatology, 2024‏ - e-cmh.org
Transcriptomic signature in advanced hepatocellular carcinoma tissue to predict combination
immunotherapy response Authors Hiro Page 1 Transcriptomic signature in advanced …

ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma

H Ma, Y Hong, Z Xu, Z Weng, Y Yang, D **, Z Chen… - Scientific Reports, 2025‏ - nature.com
As immune-checkpoint inhibitors (ICIs) therapy has made great strides in hepatocellular
carcinoma (HCC) treatment, improving patient response to this strategy has become the …

Breaking the Barriers of Therapy Resistance: Harnessing Ferroptosis for Effective Hepatocellular Carcinoma Therapy

X Lv, G Lan, L Zhu, Q Guo - Journal of Hepatocellular Carcinoma, 2024‏ - Taylor & Francis
Ferroptosis is a type of cell death that relies on iron and is distinguished by the occurrence of
lipid peroxidation and the buildup of reactive oxygen species. Ferroptosis has been …

Prognosis prediction of α-FAtE score for locoregional immunotherapy in hepatocellular carcinoma

Z Zheng, R Guan, R Zhao, J Gan, X **ong… - Frontiers in …, 2025‏ - frontiersin.org
Purpose The α-FAtE score, composed of alpha-fetoprotein, alkaline phosphatase, and
eosinophil levels, has been reported as a predictor of prognosis in hepatocellular carcinoma …

[HTML][HTML] Peripheral blood PD-1+ T lymphocytes as biomarkers in liquid biopsies for solid tumors: Clinical significance and prognostic applications

M Piao, N Zhang, J Li, C Li, Z Xun, L Zhang… - International …, 2025‏ - Elsevier
A shift toward a T cell exhaustion phenotype is associated with the upregulation of
expression of programmed cell death protein 1 (PD-1) on T lymphocytes in patients with …