Functional nucleic acid biosensors utilizing rolling circle amplification

RM Bialy, A Mainguy, Y Li, JD Brennan - Chemical Society Reviews, 2022‏ - pubs.rsc.org
Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …

Advances in nucleic acid amplification techniques (NAATs): COVID-19 point-of-care diagnostics as an example

T Kang, J Lu, T Yu, Y Long, G Liu - Biosensors and Bioelectronics, 2022‏ - Elsevier
Achieving superhigh sensitivity is the ultimate goal for bio-detection in modern analytical
science and life science. Among variable signal amplification strategies, nucleic acid …

Ultrasensitive DNA origami plasmon sensor for accurate detection in circulating tumor DNAs

Z Chen, C Meng, X Wang, J Chen… - Laser & Photonics …, 2024‏ - Wiley Online Library
Early lung cancer screening by computed tomography is hampered by pulmonary nodules
caused by massive COVID‐19 infections, necessitating an ultrasensitive approach for the …

A highly sensitive CRISPR‐empowered surface plasmon resonance sensor for diagnosis of inherited diseases with femtomolar‐level real‐time quantification

F Zheng, Z Chen, J Li, R Wu, B Zhang, G Nie… - Advanced …, 2022‏ - Wiley Online Library
The clustered regularly interspaced short palindromic repeats (CRISPR) molecular system
has emerged as a promising technology for the detection of nucleic acids. Herein, the …

CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules

W Feng, AM Newbigging, J Tao, Y Cao, H Peng… - Chemical …, 2021‏ - pubs.rsc.org
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-
associated (Cas) protein systems have transformed the field of genome editing and …

Pyroelectric-effect-assisted near-infrared-driven photoelectrochemical biosensor based on exponential DNA amplifier for MicroRNA detection

H Wang, L Guo, Q Du, Y Zhou, Q Yu, S Lv… - Analytical …, 2023‏ - ACS Publications
Although near-infrared responsive photoelectrochemical (PEC) biosensors have less
damage to biological components compared to UV–visible light, they still reveal an inferior …

MicroRNAs in extracellular vesicles: Sorting mechanisms, diagnostic value, isolation, and detection technology

D Xu, K Di, B Fan, J Wu, X Gu, Y Sun… - … in bioengineering and …, 2022‏ - frontiersin.org
MicroRNAs (miRNAs) are a class of short, single-stranded, noncoding RNAs, with a length
of about 18–22 nucleotides. Extracellular vesicles (EVs) are derived from cells and play a …

CRISPR/Cas12a-assisted ligation-initiated loop-mediated isothermal amplification (CAL-LAMP) for highly specific detection of microRNAs

M Zhang, H Wang, H Wang, F Wang, Z Li - Analytical Chemistry, 2021‏ - ACS Publications
Loop-mediated isothermal amplification (LAMP) has been increasingly applied in nucleic
acid detection for clinical diagnosis and monitoring pathogenic microorganisms due to its …

Palindromic molecular beacon based Z-scheme BiOCl-Au-CdS photoelectrochemical biodetection

R Zeng, Z Luo, L Su, L Zhang, D Tang… - Analytical …, 2019‏ - ACS Publications
This work presented an innovative and rationally engineered palindromic molecular beacon
(PMB) based “Z-scheme” photoelectrochemical (PEC) biosensing protocol for the selective …

Thermophoretic detection of exosomal microRNAs by nanoflares

J Zhao, C Liu, Y Li, Y Ma, J Deng, L Li… - Journal of the American …, 2020‏ - ACS Publications
Exosomal microRNAs (miRNAs) are reliable and noninvasive biomarkers for the early
diagnosis of cancer. Yet, accurate and feasible detection of exosomal miRNAs is often …