In eukaryotic cells, ATP generation is generally viewed as the primary function of
mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are …

Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …

Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Endogenous essential metal ions play an important role in many life processes, especially in
tumor development and immune response. The approval of various metallodrugs for tumor …

Tumor-associated macrophages (TAM) are prominent components of tumor
microenvironment (TME) and capable of promoting cancer progression. However, the …

Redox equilibria and the modulation of redox signalling play crucial roles in physiological
processes. Overproduction of reactive oxygen species (ROS) disrupts the body's antioxidant …

Abstract Development of enzyme mimics for the scavenging of excessive mitochondrial
superoxide (O2•−) can serve as an effective strategy in the treatment of many diseases …

Superoxide dismutase (SOD) is an antioxidant enzyme functional for physiological defense
strategies in animals and plants against free radicals and reactive oxygen species (ROS) …