Repositioning TH cell polarization from single cytokines to complex help

S Tuzlak, AS Dejean, M Iannacone, FJ Quintana… - Nature …, 2021‏ - nature.com
When helper T (TH) cell polarization was initially described three decades ago, the TH cell
universe grew dramatically. New subsets were described based on their expression of few …

Multiple sclerosis: mechanisms and immunotherapy

C Baecher-Allan, BJ Kaskow, HL Weiner - Neuron, 2018‏ - cell.com
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

The immunobiology of the interleukin-12 family: room for discovery

EDT Wojno, CA Hunter, JS Stumhofer - Immunity, 2019‏ - cell.com
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

Cytokine networks in neuroinflammation

B Becher, S Spath, J Goverman - Nature Reviews Immunology, 2017‏ - nature.com
Cytokines provide cells with the ability to communicate with one another and orchestrate
complex multicellular behaviour. There is an emerging understanding of the role that …

The role of TH17 cells in multiple sclerosis: Therapeutic implications

T Moser, K Akgün, U Proschmann, J Sellner… - Autoimmunity …, 2020‏ - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

GM-CSF: from growth factor to central mediator of tissue inflammation

B Becher, S Tugues, M Greter - Immunity, 2016‏ - cell.com
The granulocyte-macrophage colony-stimulating factor (GM-CSF) was initially classified as a
hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) …

IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice

M Andreadou, F Ingelfinger, D De Feo… - Nature …, 2023‏ - nature.com
Abstract Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in
autoimmune conditions, including of the CNS, IL-12 reduces inflammation. The underlying …

[HTML][HTML] T helper cells: the modulators of inflammation in multiple sclerosis

M Kunkl, S Frascolla, C Amormino, E Volpe, L Tuosto - Cells, 2020‏ - mdpi.com
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

CS Constantinescu, N Farooqi… - British journal of …, 2011‏ - Wiley Online Library
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

T cell factor 1: A master regulator of the T cell response in disease

G Escobar, D Mangani, AC Anderson - Science immunology, 2020‏ - science.org
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of …