Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

This review of major depressive disorder is a comprehensive account of the genetic,
biochemical, and neurophysiological changes that have been implicated in the disorder. No …

The treatment of schizophrenia has evolved over the past half century primarily in the
context of antipsychotic drug development. Although there has been significant progress …

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …

Since currently available antipsychotic medications predominantly treat hallucinations,
delusions, disorganized thoughts and behavior, and related agitation/aggression, attention …

Background Negative symptoms in schizophrenia concern a clinically relevant reduction of
goal-directed behavior that strongly and negatively impacts daily functioning. Existing …

Introduction The circulation of large amounts of dehydroepiandrosterone (DHEA) and its
sulfated derivative (DHEA‐S) suggests a physiological role in human physiology. In the …

BACKGROUND: Alterations in the γ-amino-butyric acid (GABA) neurotransmitter system
have been identified in some populations with posttraumatic stress disorder (PTSD) …

Context Alternative and over-the-counter medicines have become increasingly popular
choices for many patients who prefer not to take traditional antidepressants. The adrenal …

The term “neurosteroid”(NS) was introduced by Baulieu in 1981 to name a steroid hormone,
dehydroepiandrosterone sulfate (DHEAS), that was found at high levels in the brain long …