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Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …
Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
CRISPR‐cas biochemistry and CRISPR‐based molecular diagnostics
Polymerase chain reaction (PCR)‐based nucleic acid testing has played a critical role in
disease diagnostics, pathogen surveillance, and many more. However, this method requires …
disease diagnostics, pathogen surveillance, and many more. However, this method requires …
Structures, mechanisms and applications of RNA-centric CRISPR–Cas13
Prokaryotes are equipped with a variety of resistance strategies to survive frequent viral
attacks or invading mobile genetic elements. Among these, CRISPR–Cas surveillance …
attacks or invading mobile genetic elements. Among these, CRISPR–Cas surveillance …
CRISPR-Cas based virus detection: Recent advances and perspectives
L Yin, S Man, S Ye, G Liu, L Ma - Biosensors and Bioelectronics, 2021 - Elsevier
Viral infections are one of the most intimidating threats to human beings. One convincing
example is the coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2. Rapid …
example is the coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2. Rapid …
Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
Principles and applications of nucleic acid strand displacement reactions
Dynamic DNA nanotechnology, a subfield of DNA nanotechnology, is concerned with the
study and application of nucleic acid strand-displacement reactions. Strand-displacement …
study and application of nucleic acid strand-displacement reactions. Strand-displacement …
History of CRISPR-Cas from encounter with a mysterious repeated sequence to genome editing technology
Y Ishino, M Krupovic, P Forterre - Journal of bacteriology, 2018 - journals.asm.org
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are well-
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …
Tools for translation: non-viral materials for therapeutic mRNA delivery
In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
Next-generation stem cells—ushering in a new era of cell-based therapies
EA Kimbrel, R Lanza - Nature Reviews Drug Discovery, 2020 - nature.com
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …
decades. This has primarily involved the transplantation of primary cells such as …