Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Human organoids: model systems for human biology and medicine

J Kim, BK Koo, JA Knoblich - Nature reviews Molecular cell biology, 2020 - nature.com
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

CRISPR‐cas biochemistry and CRISPR‐based molecular diagnostics

Z Weng, Z You, J Yang, N Mohammad… - Angewandte Chemie …, 2023 - Wiley Online Library
Polymerase chain reaction (PCR)‐based nucleic acid testing has played a critical role in
disease diagnostics, pathogen surveillance, and many more. However, this method requires …

Structures, mechanisms and applications of RNA-centric CRISPR–Cas13

H Yang, DJ Patel - Nature chemical biology, 2024 - nature.com
Prokaryotes are equipped with a variety of resistance strategies to survive frequent viral
attacks or invading mobile genetic elements. Among these, CRISPR–Cas surveillance …

CRISPR-Cas based virus detection: Recent advances and perspectives

L Yin, S Man, S Ye, G Liu, L Ma - Biosensors and Bioelectronics, 2021 - Elsevier
Viral infections are one of the most intimidating threats to human beings. One convincing
example is the coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2. Rapid …

Regulatory R-loops as facilitators of gene expression and genome stability

C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

Principles and applications of nucleic acid strand displacement reactions

FC Simmel, B Yurke, HR Singh - Chemical reviews, 2019 - ACS Publications
Dynamic DNA nanotechnology, a subfield of DNA nanotechnology, is concerned with the
study and application of nucleic acid strand-displacement reactions. Strand-displacement …

History of CRISPR-Cas from encounter with a mysterious repeated sequence to genome editing technology

Y Ishino, M Krupovic, P Forterre - Journal of bacteriology, 2018 - journals.asm.org
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are well-
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …

Tools for translation: non-viral materials for therapeutic mRNA delivery

KA Hajj, KA Whitehead - Nature Reviews Materials, 2017 - nature.com
In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …

Next-generation stem cells—ushering in a new era of cell-based therapies

EA Kimbrel, R Lanza - Nature Reviews Drug Discovery, 2020 - nature.com
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …