An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Although lung cancer risk among smokers is dependent on smoking dose, it remains
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …

Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic
alterations are induced by aging, mutagenic chemicals, ultraviolet light, and other factors; …

The integrity and composition of the tumour microenvironment (TME) is highly plastic,
undergoing constant remodelling in response to instructive signals derived from alterations …

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …

Physical activity reduces cancer-associated mortality through multiple mechanisms,
including tumor immune microenvironment (TIME) reprogramming. However, whether and …

Ageing is associated with a decline in the number and fitness of adult stem cells 1, 2. Ageing-
associated loss of stemness is posited to suppress tumorigenesis 3, 4, but this hypothesis …

BACKGROUND Endometriosis is a benign gynaecological disease. Thus, it came as a
complete surprise when it was reported recently that the majority of deep endometriosis …

Individuals with short telomeres should be at increased risk for cancer, since short telomeres
lead to genomic instability–a hallmark of cancer. However, individuals with long telomeres …