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Applications of π-π stacking interactions in the design of drug-delivery systems
WR Zhuang, Y Wang, PF Cui, L **ng, J Lee… - Journal of controlled …, 2019 - Elsevier
Noncovalent forces are of considerable importance in the formation of self-assembled drug-
delivery systems. In addition to non-destructively linking the delivery vehicle and guest drug …
delivery systems. In addition to non-destructively linking the delivery vehicle and guest drug …
Nitro-group-containing drugs
The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …
[HTML][HTML] Azo dyes in clothing textiles can be cleaved into a series of mutagenic aromatic amines which are not regulated yet
Azo dyes represent the by far most important class of textile dyes. Their biotransformation by
various skin bacteria may release aromatic amines (AAs) which might be dermally absorbed …
various skin bacteria may release aromatic amines (AAs) which might be dermally absorbed …
Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
Predicting toxicities of reactive metabolite–positive drug candidates
Because of the inability to predict and quantify the risk of idiosyncratic adverse drug
reactions (IADRs) and because reactive metabolites (RMs) are thought to be responsible for …
reactions (IADRs) and because reactive metabolites (RMs) are thought to be responsible for …
Discovery and early clinical development of an inhibitor of 5-lipoxygenase activating protein (AZD5718) for treatment of coronary artery disease
D Pettersen, J Broddefalk, H Emtenäs, MA Hayes… - 2019 - ACS Publications
5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway
activity and reduce the production of proinflammatory and vasoactive leukotrienes. As such …
activity and reduce the production of proinflammatory and vasoactive leukotrienes. As such …
Mechanism-based insights into removing the mutagenicity of aromatic amines by small structural alterations
Aromatic and heteroaromatic amines (ArNH2) are activated by cytochrome P450
monooxygenases, primarily CYP1A2, into reactive N-arylhydroxylamines that can lead to …
monooxygenases, primarily CYP1A2, into reactive N-arylhydroxylamines that can lead to …
Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in …
M Chevereau, H Glatt, D Zalko, JP Cravedi… - Archives of …, 2017 - Springer
Heterocyclic aromatic amines (HAAs) are primarily produced during the heating of meat or
fish. HAAs are mutagenic and carcinogenic, and their toxicity in model systems depend on …
fish. HAAs are mutagenic and carcinogenic, and their toxicity in model systems depend on …
Should the incorporation of structural alerts be restricted in drug design? An analysis of structure-toxicity trends with aniline-based drugs
Certain idiosyncratic adverse drug reactions (IADRs) can be triggered by electrophilic
protein-reactive metabolites that are formed in the process of drug metabolism. While …
protein-reactive metabolites that are formed in the process of drug metabolism. While …
Cascade Reaction of Arylboronic Acids and 2′-Cyano-biaryl-2-aldehyde N-Tosylhydrazones: Access to Functionalized 9-Amino-10-arylphenanthrenes
Y Liu, L Chen, Z Wang, P Liu, Y Liu… - The Journal of Organic …, 2018 - ACS Publications
An efficient, general, and convenient protocol for the synthesis of functionalized 9-amino-10-
arylphenanthrene derivatives using a catalyst-free cascade reaction of arylboronic acids and …
arylphenanthrene derivatives using a catalyst-free cascade reaction of arylboronic acids and …