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Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma
Although once daily anti-glaucoma drug therapy is a current clinical reality, most therapies
require multiple dosing and there is an unmet need to develop convenient, safe, and …
require multiple dosing and there is an unmet need to develop convenient, safe, and …
Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress
Y Shen, J Sun, X Sun - Journal of Nanobiotechnology, 2023 - Springer
Glaucoma is a leading cause of irreversible visual impairment and blindness, affecting over
76.0 million people worldwide in 2020, with a predicted increase to 111.8 million by 2040 …
76.0 million people worldwide in 2020, with a predicted increase to 111.8 million by 2040 …
Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy
X Fu, S Feng, H Qin, L Yan, C Zheng… - Frontiers in molecular …, 2023 - frontiersin.org
Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-
time and facilitate angiogenesis during retinal development. In certain retinal diseases, the …
time and facilitate angiogenesis during retinal development. In certain retinal diseases, the …
Nanostructured dense collagen‐polyester composite hydrogels as amphiphilic platforms for drug delivery
Associating collagen with biodegradable hydrophobic polyesters constitutes a promising
method for the design of medicated biomaterials. Current collagen‐polyester composite …
method for the design of medicated biomaterials. Current collagen‐polyester composite …
Simultaneous co-delivery of neuroprotective drugs from multi-loaded PLGA microspheres for the treatment of glaucoma
Glaucoma is a multifactorial neurodegenerative disorder and one of the leading causes of
irreversible blindness globally and for which intraocular pressure is the only modifiable risk …
irreversible blindness globally and for which intraocular pressure is the only modifiable risk …
[HTML][HTML] Porous poly (ε-caprolactone) implants: A novel strategy for efficient intraocular drug delivery
R Boia, PAN Dias, JM Martins… - Journal of Controlled …, 2019 - Elsevier
This work reports the development of porous poly (ε-caprolactone)(PCL)-based intraocular
implants, prepared by green supercritical carbon dioxide (scCO 2) foaming/mixing method …
implants, prepared by green supercritical carbon dioxide (scCO 2) foaming/mixing method …
[HTML][HTML] Biodegradable microspheres come into sight: A promising biomaterial for delivering drug to the posterior segment of the eyeball
R Xue, H Wu, S Li, N Pu, D Wei, N Zhao, Y Cui, H Li… - Materials Today Bio, 2024 - Elsevier
Posterior segment disease acts as a major cause of irreversible visual impairments.
Successful treatment of posterior segment disease requires the efficient delivery of …
Successful treatment of posterior segment disease requires the efficient delivery of …
Finerenone, a non-steroidal mineralocorticoid receptor antagonist, reduces vascular injury and increases regulatory T-cells: studies in rodents with diabetic and …
Vision loss in diabetic retinopathy features damage to the blood–retinal barrier and
neovascularization, with hypertension and the renin–angiotensin system (RAS) having …
neovascularization, with hypertension and the renin–angiotensin system (RAS) having …
Recent advance of nanoparticle-based topical drug delivery to the posterior segment of the eye
Y Wang, X Xu, Y Gu, Y Cheng, F Cao - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Considering that the number of patients afflicted by posterior eye diseases is
increasing, effective drug delivery is currently in high clinical demand. Topical administration …
increasing, effective drug delivery is currently in high clinical demand. Topical administration …
Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular …
M Zhao, I Mantel, E Gelize, X Li, X **e… - Nature …, 2019 - nature.com
Choroidal neovascularization (CNV) is a major cause of visual impairment in patients
suffering from wet age-related macular degeneration (AMD), particularly when refractory to …
suffering from wet age-related macular degeneration (AMD), particularly when refractory to …