Flavonoids: A treasure house of prospective pharmacological potentials

H Hasnat, SA Shompa, MM Islam, S Alam, FT Richi… - Heliyon, 2024‏ - cell.com
Flavonoids are organic compounds characterized by a range of phenolic structures, which
are abundantly present in various natural sources such as fruits, vegetables, cereals, bark …

The importance of flavonoids and phytochemicals of medicinal plants with antiviral activities

MH Shahrajabian, W Sun… - Mini-Reviews in Organic …, 2022‏ - benthamdirect.com
In this mini-review article, we have mentioned the key roles of some of the most important
herbal plants medicine containing flavonoids and phytochemicals with antiviral activities. All …

Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E

R Kumar, M Afsar, N Khandelwal, Y Chander, T Riyesh… - Antiviral research, 2021‏ - Elsevier
Emetine is a FDA-approved drug for the treatment of amebiasis. Previously we
demonstrated the antiviral efficacy of emetine against some RNA and DNA viruses. In this …

Potential of green-synthesized selenium nanoparticles using apigenin in human breast cancer MCF-7 cells

AM Al-Otaibi, AS Al-Gebaly, R Almeer… - … Science and Pollution …, 2022‏ - Springer
The utilization of novel compounds as cancer treatments offers enormous potential in this
field. The advantages of nanomedicine-based therapy include efficient cellular uptake and …

Apigenin analogues as SARS-CoV-2 main protease inhibitors: In-silico screening approach

A Farhat, H Ben Hlima, B Khemakhem… - …, 2022‏ - Taylor & Francis
The COVID-19 new variants spread rapidly all over the world, and until now scientists strive
to find virus-specific antivirals for its treatment. The main protease of SARS-CoV-2 (Mpro) …

S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for …

R Kumar, N Khandelwal, Y Chander, H Nagori… - Antiviral research, 2022‏ - Elsevier
We report the in vitro antiviral activity of DZNep (3-Deazaneplanocin A; an inhibitor of S-
adenosylmethionine-dependent methyltransferase) against SARS-CoV-2, besides …

Role of p38 mitogen‐activated protein kinase signalling in virus replication and potential for develo** broad spectrum antiviral drugs

Y Chander, R Kumar, N Khandelwal… - Reviews in Medical …, 2021‏ - Wiley Online Library
Mitogen‐activated protein kinases (MAPKs) play a key role in complex cellular processes
such as proliferation, development, differentiation, transformation and apoptosis. Mammals …

Resistance evolution against host-directed antiviral agents: Buffalopox virus switches to use p38-ϒ under long-term selective pressure of an inhibitor targeting p38-α

Y Chander, R Kumar, A Verma… - Molecular biology …, 2022‏ - academic.oup.com
Host-dependency factors have increasingly been targeted to minimize antiviral drug
resistance. In this study, we have demonstrated that inhibition of p38 mitogen-activated …

Hesperetin blocks poxvirus replication with a low tendency to select for drug‐resistant viral variants

A Verma, RK Dedar, R Kumar… - Journal of Medical …, 2024‏ - Wiley Online Library
In this study, we demonstrated the antiviral efficacy of hesperetin against multiple
poxviruses, including buffalopox virus (BPXV), vaccinia virus (VACV), and lumpy skin …

Phytochemicals, Biological Activities, Molecular Mechanisms, and Future Prospects of Plantago asiatica L.

SY Wen, BY Wei, JQ Ma, L Wang… - Journal of Agricultural …, 2022‏ - ACS Publications
Plantago asiatica L. has been used as a vegetable and nutritious food in Asia for thousands
of years. According to recent phytochemical and pharmacological research, the active …