The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the
metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating …

Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors
mainly occurring in children, adolescents and young adults. Current standard therapy …

Matrix dynamics influence how individual cells develop into complex multicellular tissues.
Here, we develop hydrogels with identical polymer components but different crosslinking …

Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides
instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a …

Background Breast cancer cells recruit surrounding stromal cells, such as cancer-associated
fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the …

Abstract Purpose of Review This review presents a selection of regulatory molecules of
tumor microenvironmental properties and metastasis. Signaling pathways controlling …

Background Hypoxia promotes cancer progression. Hypoxia-inducible factor-1α (HIF-1α)
has been reported to enhance tumor invasion and metastasis via activating downstream …

Background Microsatellite instability‐high (MSI‐H) subgroup of gastric cancer (GC) is
characterized by a high tumor mutational burden, increased lymphocytic infiltration, and …