Post-cardiac arrest brain injury (PCABI) is caused by initial ischaemia and subsequent
reperfusion of the brain following resuscitation. In those who are admitted to intensive care …

Critical care uses syndromic definitions to describe patient groups for clinical practice and
research. There is growing recognition that a “precision medicine” approach is required and …

Rationale: Secondary brain hypoxia portends significant mortality in ischemic brain
diseases; yet, our understanding of hypoxic ischemic brain injury (HIBI) pathophysiology in …

The cerebral oxygen cascade includes three key stages:(a) convective oxygen delivery
representing the bulk flow of oxygen to the cerebral vascular bed;(b) diffusion of oxygen from …

Although there is growing interest in the use of brain tissue oxygenation as a resuscitative
endpoint, many of these therapies are based on physiologic principles with little robust …

Cerebral multimodality monitoring (MMM) is, even with a general lack of Class I evidence,
increasingly recognized as a tool to support clinical decision-making in the neuroscience …

Background Impaired cerebrovascular reactivity (CVR) is one feature of post cardiac arrest
encephalopathy. We studied the incidence and features of CVR by near infrared …

PURPOSE: Following return of spontaneous circulation after cardiac arrest, hypoxic
ischemic brain injury is the primary cause of mortality and disability. Goal-directed care …

The use of cerebral autoregulation monitoring to identify patient-specific optimal mean
arterial pressure (MAP OPT) has emerged as a technique to augment cerebral oxygen …

Purpose This study aimed to assess the effect of different blood pressure levels on global
cerebral metabolism in comatose patients resuscitated from out-of-hospital cardiac arrest …