Current status and development of nuclear physics methods of proton therapy at the Lebedev Physical Institute

IN Zavestovskaya, AV Kolobov, VA Ryabov - Uspekhi Fizicheskikh Nauk, 2024 - ufn.ru
The review is devoted to the development of promising new technologies for diagnostics
and radiotherapy in oncology using the Prometheus proton therapy complex based on the …

Temporally feathered intensity‐modulated radiation therapy: A planning technique to reduce normal tissue toxicity

JC López Alfonso, S Parsai, N Joshi, A Godley… - Medical …, 2018 - Wiley Online Library
Purpose Intensity‐modulated radiation therapy (IMRT) has allowed optimization of three‐
dimensional spatial radiation dose distributions permitting target coverage while reducing …

Spatiotemporal fractionation schemes for stereotactic radiosurgery of multiple brain metastases

N Torelli, D Papp, J Unkelbach - Medical physics, 2023 - Wiley Online Library
Background Stereotactic radiosurgery (SRS) is an established treatment for patients with
brain metastases (BMs). However, damage to the healthy brain may limit the tumor dose for …

A novel stochastic optimization method for handling misalignments of proton and photon doses in combined treatments

S Fabiano, N Torelli, D Papp… - Physics in Medicine & …, 2022 - iopscience.iop.org
Objective. Combined proton–photon treatments, where most fractions are delivered with
photons and only a few are delivered with protons, may represent a practical approach to …

Mathematical modelling for spatial optimization of irradiation during proton radiotherapy with nanosensitizers

M Kuznetsov, A Kolobov - Russian Journal of Numerical Analysis …, 2023 - degruyter.com
A spatially distributed mathematical model is presented that simulates the growth of a non-
invasive tumour undergoing treatment by fractionated proton therapy with the use of non …

[HTML][HTML] Joint optimization of photon–carbon ion treatments for Glioblastoma

ABA Bennan, J Unkelbach, N Wahl, P Salome… - International Journal of …, 2021 - Elsevier
Purpose Carbon ions are radiobiologically more effective than photons and are beneficial
for treating radioresistant gross tumor volumes (GTV). However, owing to a reduced …

Robust spatiotemporal fractionation schemes in the presence of patient setup uncertainty

MR Gaddy, J Unkelbach, D Papp - Medical physics, 2019 - Wiley Online Library
Purpose Spatiotemporal fractionation schemes for photon radiotherapy have recently arisen
as a promising technique for healthy tissue sparing. Because spatiotemporally fractionated …

Spatiotemporal Fractionation in Radiotherapy

N Torelli - 2024 - zora.uzh.ch
In current clinical practice, radiotherapy treatments are often fractionated, ie the total
radiation dose is equally divided into small fractions to be delivered daily over a period of …

Daily waiting and treatment times at an advanced radiation oncology setup: a 4-year audit of consecutive patients from single institution

A Munshi, S Krishnakutty, B Sarkar… - Journal of Cancer …, 2021 - journals.lww.com
Purpose: We present our data for every single fraction for every patient treated at our center
for the past 4 years, analyzing the waiting and treatment times. Materials and Methods …

Evaluation of the efficacy of cancer drugs by using the second largest eigenvalue of metabolic cancer pathways

D Tomić, K Skala, L Kranjčević… - … Science & Systems …, 2018 - repository.medri.uniri.hr
Abstract (english) Cancer is a system with thousands of genes and proteins with the
complex interactions between them. By examining the cancer drug activity on only part of …