The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
The role of neurotensin in central nervous system pathophysiology: what is the evidence?
F St-Gelais, C Jomphe, LÉ Trudeau - Journal of Psychiatry and …, 2006 - jpn.ca
The peptide neurotensin has been studied for more than 30 years. Although it is widely
distributed in the central and peripheral nervous systems, neurotensin has been more …
distributed in the central and peripheral nervous systems, neurotensin has been more …
Noninvasive biomarkers of colorectal cancer: role in diagnosis and personalised treatment perspectives
Colorectal cancer (CRC) is the third leading cause of cancer‐related deaths worldwide. It
has been estimated that more than one‐third of patients are diagnosed when CRC has …
has been estimated that more than one‐third of patients are diagnosed when CRC has …
Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells
D Darmoul, V Gratio, H Devaud, T Lehy… - The American journal of …, 2003 - Elsevier
The traditional view on the role of serine proteases in tumor biology has changed with the
recent discovery of a family of protease-activated receptors (PARs). In this study we explored …
recent discovery of a family of protease-activated receptors (PARs). In this study we explored …
Neurotensin pathway in digestive cancers and clinical applications: an overview
N Christou, S Blondy, V David, M Verdier… - Cell Death & …, 2020 - nature.com
Initially, NEUROTENSIN (NTS) has been shown to play physiological and biological
functions as a neuro-transmitter/modulator in the central nervous system and as an …
functions as a neuro-transmitter/modulator in the central nervous system and as an …
Neurotensin and its high affinity receptor 1 as a potential pharmacological target in cancer therapy
Z Wu, D Martinez-Fong, J Trédaniel… - Frontiers in …, 2013 - frontiersin.org
Cancer is a worldwide health problem. Personalized treatment represents a future
advancement for cancer treatment, in part due to the development of targeted therapeutic …
advancement for cancer treatment, in part due to the development of targeted therapeutic …
Neurotensin signaling activates microRNAs-21 and-155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors
BACKGROUND & AIMS: Neurotensin promotes inflammation and colon cancer via the
neurotensin-1 receptor (NTR1). MicroRNAs (miR) regulate protein synthesis by degrading or …
neurotensin-1 receptor (NTR1). MicroRNAs (miR) regulate protein synthesis by degrading or …
Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2
D Darmoul, JC Marie, H Devaud, V Gratio… - British journal of …, 2001 - nature.com
Abstract The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is
cleaved and activated by trypsin. We investigated the expression of PAR-2 and the role of …
cleaved and activated by trypsin. We investigated the expression of PAR-2 and the role of …
Neurotensin receptor 1 determines the outcome of non–small cell lung cancer
Purpose: This study aimed to investigate the role of the neurotensin/neurotensin receptor I
(NTSR1) complex in non–small cell lung cancer (NSCLC) progression. Experimental …
(NTSR1) complex in non–small cell lung cancer (NSCLC) progression. Experimental …
Orexins acting at native OX1 receptor in colon cancer and neuroblastoma cells or at recombinant OX1 receptor suppress cell growth by inducing apoptosis
P Rouet-Benzineb, C Rouyer-Fessard, A Jarry… - Journal of Biological …, 2004 - ASBMB
Screening of 26 gut peptides for their ability to inhibit growth of human colon cancer HT29-
D4 cells grown in 10% fetal calf serum identified orexin-A and orexin-B as anti-growth …
D4 cells grown in 10% fetal calf serum identified orexin-A and orexin-B as anti-growth …