Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity,
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …

Necrotic cell death during Mycobacterium tuberculosis (Mtb) infection is considered host
detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated …

N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing
and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing …

Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …

Persistence, manifested as drug tolerance, represents a significant obstacle to global
tuberculosis control. The bactericidal drugs isoniazid and rifampicin kill greater than 99% of …

Macrophages are the host cells and the frontline defense against Mycobacterium
tuberculosis (Mtb) infection, and the form of death of infected macrophages plays a pivotal …

Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-
dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) …

Lysosomal cathepsin B (CTSB) has been proposed to play a role in the induction of acute
inflammation. We hypothesised that the presence of active CTSB in the cytosol is crucial for …