In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenoty** of Transgenic and Knockout Mice, continues to field calls …

Because little comparative information is available concerning receptor profiles of
antiparkinson drugs, affinities of 14 agents were determined at diverse receptors implicated …

Involuntary movements—or dyskinesias—are a debilitating complication of levodopa
therapy for Parkinson's disease that is experienced by most patients. Despite the importance …

In contrast to dopamine D1 receptors, the anatomical distribution of D5 receptors in the CNS
is poorly described. Therefore, we have studied the localization of dopamine D5 receptors in …

▪ Abstract Dopaminergic receptors are widespread throughout the central and peripheral
nervous systems, where they regulate a variety of physiological, behavioral, and endocrine …

Dopamine is an important transmitter in the CNS and PNS, critically regulating numerous
neuropsychiatric and physiological functions. These actions of dopamine are mediated by …

Multiple lines of evidence indicate that cholinergic basal forebrain neurons play an important
role in the regulation of cortical activity and state. However, the discharge properties of …

To study behavioral functions of the D₅ subtype, mice were generated with null mutations in
the D₅ gene. This 1st behavioral characterization of D₅ null mutant mice (D₅-/-) indicated …