Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …

Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …

As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Stress, primarily processed via the hypothalamic-pituitary-adrenal (HPA) axis, engages
biological pathways throughout the brain and body which promote adaptation and survival …

Traumatic brain injury (TBI) accelerates fracture healing, but the underlying mechanism
remains largely unknown. Accumulating evidence indicates that the central nervous system …

Abstract Purpose of Review The traditionally understated role of neural regulation in fracture
healing is gaining prominence, as recent findings underscore the peripheral nervous …

Mental traumatization is associated with long-bone growth retardation, osteoporosis and
increased fracture risk. We revealed earlier that mental trauma disturbs cartilage-to-bone …