Polymers, ceramics and metals have historically dominated the application of materials in
medicine. Yet rationally designed materials that exploit specific, directional, tunable and …

Conspectus Peptide amphiphiles (PAs) are small molecules that contain hydrophobic
components covalently conjugated to peptides. In this Account, we describe recent …

The extracellular matrix (ECM) is a dynamic environment that constantly provides physical
and chemical cues to embedded cells. Much progress has been made in engineering …

Conspectus The cytosolic delivery of biomolecules such as genes, proteins, and peptides is
of great importance for biotherapy but usually limited by multiple barriers during the process …

Many biological materials exist in non-equilibrium states driven by the irreversible
consumption of high-energy molecules like ATP or GTP. These energy-dissipating structures …

By means of two supramolecular systems—peptide amphiphiles engaged in hydrogen-
bonded β-sheets, and chromophore amphiphiles driven to assemble by π-orbital overlaps …

The rising prevalence of global antibiotic resistance evokes the urgent need for novel
antimicrobial candidates. Cationic lipopeptides have attracted much attention due to their …

Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …

Aliphatic polycarbonates have drawn attention as biodegradable polymers that can be
applied to a broad range of resorbable medical devices. In particular, poly (trimethylene …