Alcohols are abundant and attractive feedstock molecules for organic synthesis. Many
methods for their functionalization require them to first be converted into a more activated …

Methylation is a well‐known structural modification in organic and medicinal chemistry. This
review summarizes recent advances in methylation by categorizing specific methylation …

Methanol is a fundamental feedstock and is widely used in the chemical and petroleum
industries. It can serve as a C1 source to make a variety of C–C and C–N bond formation …

A general iron-catalyzed methylation has been developed using methanol as a C1 building
block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone) …

In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is
gaining ever‐increasing attention. Site‐selective incorporation of the deuterated “magic …

Herein, an efficient methodology for the synthesis of a diverse class of N-heterocyclic
moieties, such as quinoxalines, benzimidazoles and quinazolines, was developed in water …

Tandem transformation of α, β-unsaturated ketones to α-methylated ketones by utilizing
methanol as both the hydrogen and C1 sources is reported in the presence of a phosphine …

A mild, environmentally benign approach for α-methylation of ketones utilizing methanol as
the C1 source under visible light has been developed. The reaction conditions were …

The unusual nonbifunctional outer-sphere strategy was successfully utilized in develo**
an easily accessible N-heterocyclic carbene manganese (NHC-Mn) system for highly active …

The present review focuses on recent progress achieved from 2017 to March 2021 using
methanol as a C1-alkylating agent. A series of novel metal-catalyzed hydrogen-borrowing …