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Computational nosology and precision psychiatry
This article provides an illustrative treatment of psychiatric morbidity that offers an alternative
to the standard nosological model in psychiatry. It considers what would happen if we …
to the standard nosological model in psychiatry. It considers what would happen if we …
The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity
K Pierre, N Schlesinger… - Physiological …, 2016 - journals.physiology.org
Seasonal changes in environmental conditions are accompanied by significant adjustment
of multiple biological processes. In temperate regions, the day fraction, or photoperiod, is a …
of multiple biological processes. In temperate regions, the day fraction, or photoperiod, is a …
Modeling immune response and its effect on infectious disease outbreak dynamics
J Reyes-Silveyra, AR Mikler - Theoretical Biology and Medical Modelling, 2016 - Springer
Background In recent epidemiological models, immunity is incorporated as a simplified
value that determines the capacity of an individual to become infected or to transmit the …
value that determines the capacity of an individual to become infected or to transmit the …
Computational and experimental analysis reveals a requirement for eosinophil-derived IL-13 for the development of allergic airway responses in C57BL/6 mice
ER Walsh, J Thakar, K Stokes, F Huang… - The Journal of …, 2011 - journals.aai.org
Eosinophils are found in the lungs of humans with allergic asthma, as well as in the lungs of
animals in models of this disease. Increasing evidence suggests that these cells are integral …
animals in models of this disease. Increasing evidence suggests that these cells are integral …
Heterologous infection of pregnant mice induces low birth weight and modifies offspring susceptibility to malaria
Pregnancy malaria (PM) is associated with poor pregnancy outcomes, and can arise due to
relapse, recrudescence or a re-infection with heterologous parasites. We have used the …
relapse, recrudescence or a re-infection with heterologous parasites. We have used the …
Incorporating time delays in the mathematical modelling of the human immune response in viral infections
Mathematical modelling helps to describe the functional and causal relationships between
objects in the physical world. The complexity of these models increases as more …
objects in the physical world. The complexity of these models increases as more …
Estimating decay curves of neutralizing antibodies to SARS-CoV-2 infection
E Poehler, L Gibson, A Lustig… - … and Biology: A …, 2022 - academic.oup.com
Estimating the longevity of an individual's immune response to the SARS-Cov-2 virus is vital
for future planning, particularly of vaccine requirements. Neutralizing antibodies (Nabs) are …
for future planning, particularly of vaccine requirements. Neutralizing antibodies (Nabs) are …
Current trends in modeling host–pathogen interactions
S Mukherjee, A Sambarey… - … : Data Mining and …, 2013 - Wiley Online Library
The rapid emergence of infectious diseases calls for immediate attention to determine
practical solutions for intervention strategies. To this end, it becomes necessary to obtain a …
practical solutions for intervention strategies. To this end, it becomes necessary to obtain a …
Boolean modeling of cellular and molecular pathways involved in influenza infection
Systems virology integrates host‐directed approaches with molecular profiling to understand
viral pathogenesis. Self‐contained statistical approaches that combine expression profiles of …
viral pathogenesis. Self‐contained statistical approaches that combine expression profiles of …
Rule-based modelling of iron homeostasis in tuberculosis
S Ghosh, KVS Prasad, S Vishveshwara… - Molecular …, 2011 - pubs.rsc.org
To establish itself within the host system, Mycobacterium tuberculosis (Mtb) has formulated
various means of attacking the host system. One such crucial strategy is the exploitation of …
various means of attacking the host system. One such crucial strategy is the exploitation of …