Exosomes: key players in cancer and potential therapeutic strategy

J Dai, Y Su, S Zhong, L Cong, B Liu, J Yang… - Signal transduction and …, 2020 - nature.com
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

Extracellular vesicles in cancer—implications for future improvements in cancer care

R Xu, A Rai, M Chen, W Suwakulsiri… - Nature reviews Clinical …, 2018 - nature.com
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

G Chen, AC Huang, W Zhang, G Zhang, M Wu, W Xu… - Nature, 2018 - nature.com
Tumour cells evade immune surveillance by upregulating the surface expression of
programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) …

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

S Maacha, AA Bhat, L Jimenez, A Raza, M Haris… - Molecular cancer, 2019 - Springer
The tumor microenvironment represents a complex network, in which tumor cells not only
communicate with each other but also with stromal and immune cells. Current research has …

Extracellular vesicles in cancer: cell-to-cell mediators of metastasis

A Becker, BK Thakur, JM Weiss, HS Kim, H Peinado… - Cancer cell, 2016 - cell.com
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular
communication between tumor cells and stromal cells in local and distant …

Exosome-based cell-cell communication in the tumor microenvironment

J Maia, S Caja, MC Strano Moraes, N Couto… - Frontiers in cell and …, 2018 - frontiersin.org
Tumors are not isolated entities, but complex systemic networks involving cell-cell
communication between transformed and non-transformed cells. The milieu created by …

Engineering exosomes as refined biological nanoplatforms for drug delivery

X Luan, K Sansanaphongpricha, I Myers… - Acta Pharmacologica …, 2017 - nature.com
Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important
mediators of long distance intercellular communication and are involved in a diverse range …

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

FL Ricklefs, Q Alayo, H Krenzlin, AB Mahmoud… - Science …, 2018 - science.org
Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1)
leads to cancer immune evasion via inhibition of T cell function. One of the defining …

[HTML][HTML] Design strategies and application progress of therapeutic exosomes

C Liu, C Su - Theranostics, 2019 - ncbi.nlm.nih.gov
Exosomes have great potential to be drug delivery vehicles due to their natural material
transportation properties, intrinsic long-term circulatory capability, and excellent …

[HTML][HTML] The biology, function, and applications of exosomes in cancer

J Liu, L Ren, S Li, W Li, X Zheng, Y Yang, W Fu… - … Pharmaceutica Sinica B, 2021 - Elsevier
Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon
fusion of multivesicular bodies with the cell surface. They can transport nucleic acids …