Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …

Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …

Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Gliomas are intrinsic brain tumors that originate from neuroglial progenitor cells.
Conventional therapies, including surgery, chemotherapy, and radiotherapy, have achieved …

Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …

Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …

Glioblastoma multiforme (GBM) is a devastating tumor of the central nervous system,
currently missing an effective treatment. The therapeutic gold standard consists of surgical …