Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …

Huntington's disease (HD) is a progressive, fatal neurological condition caused by an
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …

Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …

Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …

The corticostriatal pathway provides most of the excitatory glutamatergic input into the
striatum and it plays an important role in the development of the phenotype of Huntington's …

Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …

Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …

Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and
behavioral dysfunctions, such as progressive loss of coordination and memory, and share …