The crucial roles of phospholipids in aging and lifespan regulation

Y Dai, H Tang, S Pang - Frontiers in Physiology, 2021 - frontiersin.org
Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular
structure acts as a barrier to protect the cell against various environmental insults and more …

Centenarians: An excellent example of resilience for successful ageing

C Borras, M Ingles, C Mas-Bargues, M Dromant… - Mechanisms of ageing …, 2020 - Elsevier
Centenarians are remarkable not only because of their prolonged life, but also because they
compress morbidity until the very last moments of their lives, thus being proposed as a …

High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

HB Beyene, G Olshansky, AA T. Smith, C Giles… - PLoS …, 2020 - journals.plos.org
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

On the road to unraveling the molecular functions of ether lipids

N Jiménez‐Rojo, H Riezman - FEBS letters, 2019 - Wiley Online Library
Ether lipids are glycerolipids further classified into alkyl‐ether and alkenyl‐ether (also
termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their …

Oxidative stress and exceptional human longevity: Systematic review

Á Belenguer-Varea, FJ Tarazona-Santabalbina… - Free Radical Biology …, 2020 - Elsevier
Objective Oxidative stress (OS) has been previously linked to the aging process, as have
some diseases and geriatric syndromes as frailty and sarcopenia. The aim of the present …

[HTML][HTML] Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice

J Gu, L Chen, R Sun, JL Wang, J Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurodegeneration is a pathological condition in which nervous system or neuron losses its
structure, function, or both leading to progressive neural degeneration. Growing evidence …

[HTML][HTML] Phenotypic molecular features of long-lived animal species

M Jové, N Mota-Martorell, A Fernàndez-Bernal… - Free Radical Biology …, 2023 - Elsevier
One of the challenges facing science/biology today is uncovering the molecular bases that
support and determine animal and human longevity. Nature, in offering a diversity of animal …

New insights into healthy ageing, inflammageing and frailty using metabolomics

G Abdullah, A Akpan, MM Phelan, HL Wright - Frontiers in Aging, 2024 - frontiersin.org
Human ageing is a normal process and does not necessarily result in the development of
frailty. A mix of genetic, environmental, dietary, and lifestyle factors can have an impact on …

Paraoxonases activities and polymorphisms in elderly and old-age diseases: An overview

D Levy, CO Reichert, SP Bydlowski - Antioxidants, 2019 - mdpi.com
Aging is defined as the accumulation of progressive organ dysfunction. There is much
evidence linking the involvement of oxidative stress in the pathogenesis of aging. With …

[HTML][HTML] Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis

AJ Causer, JK Shute, MH Cummings, AI Shepherd… - Redox biology, 2020 - Elsevier
Introduction Oxidative stress may play an important role in the pathophysiology of cystic
fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods …