The crucial roles of phospholipids in aging and lifespan regulation
Y Dai, H Tang, S Pang - Frontiers in Physiology, 2021 - frontiersin.org
Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular
structure acts as a barrier to protect the cell against various environmental insults and more …
structure acts as a barrier to protect the cell against various environmental insults and more …
Centenarians: An excellent example of resilience for successful ageing
Centenarians are remarkable not only because of their prolonged life, but also because they
compress morbidity until the very last moments of their lives, thus being proposed as a …
compress morbidity until the very last moments of their lives, thus being proposed as a …
High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …
burden of these diseases calls for better understanding of the age-and sex-related metabolic …
On the road to unraveling the molecular functions of ether lipids
Ether lipids are glycerolipids further classified into alkyl‐ether and alkenyl‐ether (also
termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their …
termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their …
Oxidative stress and exceptional human longevity: Systematic review
Á Belenguer-Varea, FJ Tarazona-Santabalbina… - Free Radical Biology …, 2020 - Elsevier
Objective Oxidative stress (OS) has been previously linked to the aging process, as have
some diseases and geriatric syndromes as frailty and sarcopenia. The aim of the present …
some diseases and geriatric syndromes as frailty and sarcopenia. The aim of the present …
[HTML][HTML] Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice
J Gu, L Chen, R Sun, JL Wang, J Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurodegeneration is a pathological condition in which nervous system or neuron losses its
structure, function, or both leading to progressive neural degeneration. Growing evidence …
structure, function, or both leading to progressive neural degeneration. Growing evidence …
[HTML][HTML] Phenotypic molecular features of long-lived animal species
One of the challenges facing science/biology today is uncovering the molecular bases that
support and determine animal and human longevity. Nature, in offering a diversity of animal …
support and determine animal and human longevity. Nature, in offering a diversity of animal …
New insights into healthy ageing, inflammageing and frailty using metabolomics
Human ageing is a normal process and does not necessarily result in the development of
frailty. A mix of genetic, environmental, dietary, and lifestyle factors can have an impact on …
frailty. A mix of genetic, environmental, dietary, and lifestyle factors can have an impact on …
Paraoxonases activities and polymorphisms in elderly and old-age diseases: An overview
Aging is defined as the accumulation of progressive organ dysfunction. There is much
evidence linking the involvement of oxidative stress in the pathogenesis of aging. With …
evidence linking the involvement of oxidative stress in the pathogenesis of aging. With …
[HTML][HTML] Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis
Introduction Oxidative stress may play an important role in the pathophysiology of cystic
fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods …
fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods …