Protein design: From the aspect of water solubility and stability
Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …
sequence and 3D-conformation. Their manipulation represents important aspects of the …
The R language: an engine for bioinformatics and data science
The R programming language is approaching its 30th birthday, and in the last three decades
it has achieved a prominent role in statistics, bioinformatics, and data science in general. It …
it has achieved a prominent role in statistics, bioinformatics, and data science in general. It …
Accelerating antibiotic discovery through artificial intelligence
By targeting invasive organisms, antibiotics insert themselves into the ancient struggle of the
host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics …
host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics …
[HTML][HTML] Antimicrobial peptides: Opportunities and challenges in overcoming resistance
C Bucataru, C Ciobanasu - Microbiological Research, 2024 - Elsevier
Antibiotic resistance represents a global health threat, challenging the efficacy of traditional
antimicrobial agents and necessitating innovative approaches to combat infectious …
antimicrobial agents and necessitating innovative approaches to combat infectious …
Machine learning for biologics: opportunities for protein engineering, developability, and formulation
Successful biologics must satisfy multiple properties including activity and particular
physicochemical features that are globally defined as developability. These multiple …
physicochemical features that are globally defined as developability. These multiple …
Meta-4mCpred: a sequence-based meta-predictor for accurate DNA 4mC site prediction using effective feature representation
DNA N4-methylcytosine (4mC) is an important genetic modification and plays crucial roles in
differentiation between self and non-self DNA and in controlling DNA replication, cell cycle …
differentiation between self and non-self DNA and in controlling DNA replication, cell cycle …
Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches
SARS-CoV-2 causes a severe respiratory disease called COVID-19. Currently, global health
is facing its devastating outbreak. However, there is no vaccine available against this virus …
is facing its devastating outbreak. However, there is no vaccine available against this virus …
DeepSol: a deep learning framework for sequence-based protein solubility prediction
Motivation Protein solubility plays a vital role in pharmaceutical research and production
yield. For a given protein, the extent of its solubility can represent the quality of its function …
yield. For a given protein, the extent of its solubility can represent the quality of its function …
Isoform age-splice isoform profiling using long-read technologies
Alternative splicing (AS) of RNA is a key mechanism that results in the expression of multiple
transcript isoforms from single genes and leads to an increase in the complexity of both the …
transcript isoforms from single genes and leads to an increase in the complexity of both the …
DSResSol: A sequence-based solubility predictor created with Dilated Squeeze Excitation Residual Networks
Protein solubility is an important thermodynamic parameter that is critical for the
characterization of a protein's function, and a key determinant for the production yield of a …
characterization of a protein's function, and a key determinant for the production yield of a …