Alkaline phosphatase: a reliable endogenous partner for drug delivery and diagnostics
Since the 1960s the membrane‐bound enzyme alkaline phosphatase (ALP) has been
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …
Recent advances with alkaline phosphatase isoenzymes and their inhibitors
Alkaline phosphatases are found in different living species and play crucial roles in various
significant functions, such as hydrolyzing a variable spectrum of phosphate‐containing …
significant functions, such as hydrolyzing a variable spectrum of phosphate‐containing …
Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition
JP Lallès - Nutrition reviews, 2019 - academic.oup.com
In recent years, much new data on intestinal alkaline phosphatase (IAP) have been
published, and major breakthroughs have been disclosed. The aim of the present review is …
published, and major breakthroughs have been disclosed. The aim of the present review is …
Current status of N-, O-, S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview
Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)
Infectious diseases remain a significant threat to human health, contributing to more than 17
million deaths, annually. With the worsening trends of drug resistance, there is a need for …
million deaths, annually. With the worsening trends of drug resistance, there is a need for …
2-Benzylidenebenzofuran-3 (2 H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational …
The excelling role of organic chemistry in the medicinal field continues to be one of the main
leads in the drug development process. Particularly, this industry requires organic chemists …
leads in the drug development process. Particularly, this industry requires organic chemists …
Sulfonamide moiety as “molecular chimera” in the design of new drugs
Background: The-SO2NH-group is of great significance in modern pharmaceutical use
since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small …
since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small …
Recent Advances in Synthesis and Medicinal Evaluation of 1, 2‐Benzothiazine Analogues
R Reetu, R Gujjarappa… - Asian Journal of Organic …, 2022 - Wiley Online Library
Benzothiazines are one of the significant nitrogen containing heterocyclic scaffolds which
are found to be multipurpose in the fields of drug discovery and medicinal chemistry. They …
are found to be multipurpose in the fields of drug discovery and medicinal chemistry. They …
Design, synthesis, biochemical and in silico characterization of novel naphthalene-thiourea conjugates as potential and selective inhibitors of alkaline phosphatase
Naphthalene ring is present in a number of FDA-approved, commercially available
medications, including naphyrone, terbinafine, propranolol, naproxen, duloxetine …
medications, including naphyrone, terbinafine, propranolol, naproxen, duloxetine …
Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver …
To seek the new medicinal potential of sulfadiazine drug, the free amino group of
sulfadiazine was exploited to obtain acyl/aryl thioureas using simple and straightforward …
sulfadiazine was exploited to obtain acyl/aryl thioureas using simple and straightforward …