In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

Cardiac action potential (AP) shape and propagation are regulated by several key dynamic
factors such as ion channel recovery and intracellular Ca2+ cycling. Experimental methods …

Rationale: The sarcolemma of cardiomyocytes contains many proteins that are essential for
electromechanical function in general, and excitation-contraction coupling in particular. The …

Key points Although optogenetics has clearly demonstrated the feasibility of cardiac
manipulation, current optical stimulation strategies lack the capability to react acutely to …

Rationale: Recently, abundant axial tubule (AT) membrane structures were identified deep
inside atrial myocytes (AMs). Upon excitation, ATs rapidly activate intracellular Ca2+ release …

This work deals with the stimulation of cardiac spiral waves in a two-dimensional FitzHugh–
Nagumo model through modulational instability phenomenon in the presence of intracellular …

Numerous diseases, including those of the heart, are characterized by increased stiffness
due to excessive deposition of extracellular matrix proteins. Cardiomyocytes continuously …

The control mechanisms and implications of heart rate variability (HRV) under the
sympathetic (SNS) and parasympathetic nervous system (PNS) modulation remain poorly …

Optical techniques for recording and manipulating cellular electrophysiology have advanced
rapidly in just a few decades. These developments allow for the analysis of cardiac cellular …