Brain aging mechanisms with mechanical manifestations

Y Blinkouskaya, A Caçoilo, T Gollamudi… - Mechanisms of ageing …, 2021 - Elsevier
Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Fifty shades of brain: a review on the mechanical testing and modeling of brain tissue

S Budday, TC Ovaert, GA Holzapfel… - … Methods in Engineering, 2020 - Springer
Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

M3T: three-dimensional Medical image classifier using Multi-plane and Multi-slice Transformer

J Jang, D Hwang - … of the IEEE/CVF conference on …, 2022 - openaccess.thecvf.com
In this study, we propose a three-dimensional Medical image classifier using Multi-plane
and Multi-slice Transformer (M3T) network to classify Alzheimer's disease (AD) in 3D MRI …

On automated model discovery and a universal material subroutine for hyperelastic materials

M Peirlinck, K Linka, JA Hurtado, E Kuhl - Computer Methods in Applied …, 2024 - Elsevier
Constitutive modeling is the cornerstone of computational and structural mechanics. In a
finite element analysis, the constitutive model is encoded in the material subroutine, a …

Brain shape changes associated with cerebral atrophy in healthy aging and Alzheimer's disease

Y Blinkouskaya, J Weickenmeier - Frontiers in Mechanical …, 2021 - frontiersin.org
Both healthy and pathological brain aging are characterized by various degrees of cognitive
decline that strongly correlate with morphological changes referred to as cerebral atrophy …

[HTML][HTML] A physics-based model explains the prion-like features of neurodegeneration in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

J Weickenmeier, M Jucker, A Goriely, E Kuhl - Journal of the Mechanics and …, 2019 - Elsevier
Prion disease is characterized by a chain reaction in which infectious misfolded proteins
force native proteins into a similar pathogenic structure. Recent studies have reinforced the …

Volumetric MRI findings in mild traumatic brain injury (mTBI) and neuropsychological outcome

ED Bigler - Neuropsychology Review, 2023 - Springer
Region of interest (ROI) volumetric assessment has become a standard technique in
quantitative neuroimaging. ROI volume is thought to represent a coarse proxy for making …

A universal material model subroutine for soft matter systems

M Peirlinck, JA Hurtado, MK Rausch, AB Tepole… - Engineering with …, 2024 - Springer
Soft materials play an integral part in many aspects of modern life including autonomy,
sustainability, and human health, and their accurate modeling is critical to understand their …

Chronic motor performance following different traumatic brain injury severity—A systematic review

F Corrigan, IC Wee, LE Collins-Praino - Frontiers in Neurology, 2023 - frontiersin.org
Introduction Traumatic brain injury (TBI) is now known to be a chronic disease, causing
ongoing neurodegeneration and linked to increased risk of neurodegenerative motor …

[HTML][HTML] Measures of retinal structure and function as biomarkers in neurology and psychiatry

SM Silverstein, DL Demmin, JB Schallek… - Biomarkers in …, 2020 - Elsevier
Investigators have increasingly turned to studying the retina as a window into brain structure
and function. In neuropsychiatric diseases, retinal anatomy as assessed by optical …